Prof. Mattia Sponchioni

Argomenti del programma: The lectures describe the physicochemical fundamentals of processes for the production of biopharmaceuticals. The focus will be on the manufacturing of these drugs through recombinant technology. In fact, these are typically expressed by cells cultured in suitable bioreactors and subsequently purified through various steps, referred to as capture and polishing, usually based on chromatographic techniques.

Argomenti del programma: Lectures The lectures describe the physicochemical fundamentals of processes for the production of drugs and devices for biomedical applications. The topics covered can be organized in three main parts. In the first, introductory part the background related to biopharmaceuticals, including definition, main features and market considerations are addressed.

Argomenti del programma: - Fundamental concepts (basic separation techniques and their classification, selection of feasible separations, short account of thermodynamics and mass transfer) - Adsorption Separations: adsorbent materials, characterization techniques, adsorption equilibria (pure components and mixtures, gas and liquid adsorption), kinetics and transports (sorption modes, eluted peaks and separation efficiency, correlations for…

Argomenti del programma: Lectures The lectures describe the physicochemical fundamentals of processes for the production of drugs and devices for biomedical applications. The topics covered can be organized in three main parts. In the first, introductory part the background related to biopharmaceuticals, including definition, main features and market considerations are addressed.

Argomenti del programma: The lectures describe the physicochemical fundamentals of processes for the production of biopharmaceuticals. The focus will be on the manufacturing of these drugs through recombinant technology. In fact, these are typically expressed by cells cultured in suitable bioreactors and subsequently purified through various steps, referred to as capture and polishing, usually based on chromatographic techniques.

Argomenti del programma: - Fundamental concepts (basic separation techniques and their classification, selection of feasible separations, short account of thermodynamics and mass transfer) - Adsorption Separations: adsorbent materials, characterization techniques, adsorption equilibria (pure components and mixtures, gas and liquid adsorption), kinetics and transports (sorption modes, eluted peaks and separation efficiency, correlations for…