Prof. Paola Piomboni

• Since no single textbook covers the entire scope of this integrated course, students should consult a combination of core reference texts, scientific literature, and lecture materials.
• Students must integrate the primary reference textbooks with the official teaching materials and scientific literature provided throughout the course.
• All core teaching materials—including lecture slides, selected book chapters, and curated scientific articles—are regularly uploaded to the university Moodle platform at elearning.unisi.it.

Argomenti del programma: Module 1: Reproductive Physiology and Maternal-Fetal Interaction The first section examines sperm modifications within the female genital tract, focusing on capacitation, hyperactivation, and the acrosome reaction. Students learn the molecular mechanisms of fertilization, including sperm-oocyte attraction, recognition, and egg activation, alongside the corresponding laboratory assessment of pronuclear formation.

• Students must refer to the teaching material, as well as to articles published in international journals and to guidelines from international Scientific Societies.
• The teaching material will be provided by the lecturers and will be available on Moodle:

Argomenti del programma: Topics treated in the course PART 1: Drug development process from preclinical to clinical trials; discovery and development of clinical trials; post-marketing safety monitoring. (C. Gambarana) PART 2: Animal models: history (the history and breakthrough medical discoveries based on animal research, with focus on reproduction); definitions; ethical considerations (Ethics and Animal Welfare, the 3Rs principles and…

Argomenti del programma: I contenuti dell’insegnamento di Biologia sono definiti a livello Ministeriale e sono reperibili al link: https://www.mur.gov.it/it/atti-e-normativa/decreto-ministeriale-n-418-del-30-05-2025 https://www.mur.gov.it/sites/default/files/2025- 06/Decreto%20MInisteriale%20n.%20418%20Syllabus_BIOLOGIA.pdf