Prof. Massimiliano Andreazzoli

• No textbook is required for the course. Given that much of the material in this class will be contemporary, there is no comprehensive textbook that adequately covers all topics.

Argomenti del programma: STEM CELLS Main features of stem cells. Self-renewal and differentiation. Asymmetric and symmetric cell divisions. Transit amplifying cells. Totipotency, pluripotency and multipotency. Generalities and applications of stem cells. Molecular mechanics driving cell differentiation at the morula stage. Cell fate decision leading to trophectoderm, primitive endoderm and epiblast: the role of transcription factors.

• No textbook is required for the course. Given that much of the material in this class will be contemporary, there is no comprehensive textbook that adequately covers all topics.

Argomenti del programma: STEM CELLS Main features of stem cells. Self-renewal and differentiation. Asymmetric and symmetric cell divisions. Transit amplifying cells. Totipotency, pluripotency and multipotency. Generalities and applications of stem cells. Molecular mechanics driving cell differentiation at the morula stage. Cell fate decision leading to trophectoderm, primitive endoderm and epiblast: the role of transcription factors.

Argomenti del programma: Concetto di sviluppo. Embriologia Descrittiva, Embriologia Sperimentale e Biologia dello Sviluppo. Organismi studiati come modelli di sviluppo. I PROCESSI DELLO SVILUPPO: differenziamento, specificazione regionale, morfogenesi. SVILUPPO A MOSAICO E REGOLATIVO: CONCETTI ED ESPERIMENTI. Preformismo e epigenesi. W. Roux e la nascita della Meccanica dello Sviluppo. H. Driesh: sviluppo regolativo ed equivalenza nucleare.